BIOL 2021 Lecture Notes - Lecture 8: Glycosylation, Protein Folding, Microtubule
Document Summary
Delivered to plasma membrane or extracellular space. Endocytosis: pm romeced and delivered to endosomes. Retrieval pathways (in blue: molecular return to be reused. Lumen of vesicles is topologically equivalent: does not have to go through a hole in the membrane, fuses instead) Vesicle budding and fusion: donor budding target fusion. Coat cage of proteins on cytosolic surface of vesicle. Different organelles have different pis (fig 13. 11) Different proteins will bind to different pis by shape adaptor proteins that bind to specific pis, and that initiates the formation of a clatherin coat. Functions: concentrates specific proteins in a membrane, shapes off vesicles. 3 major types: clatherin from pm between golgi and chromosomes. Cargo receptors transmembrane proteins that bind to cargo. Adaptor receptors bind receptors and clatherin. Different adaptins allow different cargo receptors to be transported. Dynamin protein pinches off the vesicle, using gtp (gtaase)