BIOL 3070 Lecture Notes - Lecture 34: Pituitary Gland, Aquaporin, Nephrogenic Diabetes Insipidus

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8 Jan 2016
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Countercurrent multiplier: responsible for initial generation of osmotic gradient in kidney, 300mosm (cortical); 1200mosm (medulla); steep gradient, slide 14. Osmotic pressure increased in isf since salt pumped out (300 400mosm) B/c descending limb highly permeable to water, water immediately drawn out of the descending limb into is. space. Now fluid in descending limb is ~400mosm. At each horizontal level, there"s a 200mosm gradient btwn the fluid in the ascending limb and the isf (ie. 100 vs 350; 300mosm in asc limb and 500 in lower regions of isf around the loop) Because desc. limb is highly permeable to water, it rapidly reaches equilibrium with whatever the interstitial fluid is (he mentioned this several times) the descending limb impermeable to salt so maintains salt concentration in desc. limb. Isf, lumen of descending limb reaches equilibrium with the. Repeat steps 2-5 many times so you multiply these effects (that"s where the coutercurrent multipler system comes from)

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