BIOLOGY 1113 Lecture Notes - Lecture 42: Tumor Suppressor Gene, Benign Tumor, P53

• School: Ohio State University
• Department: Biology
• Course: BIOLOGY 1113
• Professor: Eric Danhart

Document Summary

All credit goes to freeman biology 6th edition 2017. General term for disease caused by cells that grow in uncontrolled fashion, invading nearby tissues and spreading to other sites in body. Defects that activate the protein required for cell growth when shouldn"t be active, and defects preventing tumor suppressor genes from shutting down cell cycle. Large # of cancers have defective forms of tumor suppressor protein p53. Named for organs/tissues in which cancer originates(lung, cancer, brain). Described by type of cell that formed them(carcinoma(epithelial cells), sarcoma(bone), leukemia(bone marrow))). Malignant tumor- tumor actively growing/disrupting local tissue/spreading to other organs. body. Benign tumor- non invasive/non cancerous, mass of abnormal tissue developing due to unregulated growth, does not spread. Metastasis- spread of cancer cells from site or origin to distant sites in. Growth factors- large number of signalling molecules secreted by certain cells and stimulate other cells to grow/divide/differentiate(multicellular organisms(social control)).