PSY 359 Lecture Notes - Lecture 8: Choline Acetyltransferase, Nmda Receptor Antagonist, Nucleus Basalis Of Meynert
27 Oct 2016
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Document Summary
Umami means (good) based on finding glutamate in seaweed. There are two major glutamate receptors: ampa, nmda. Both are multiple subunits with hole in middle. Make pore bigger and an ion can go in. Long term changes in the presence of ndma: excitotoxicity- if you fire your nmda receptors long enough, you actually kill the cell with too much stimulation. *stroke* when neurons are damaged/broken they release huge amounts of glutamate. Big amount of glutamate kills cells and neighboring cells. Did not work because there is such a huge amount of glutamate. For alzheimer"s disease: plasticity and learning. When a presynaptic cell releases glutamate and allows ca++ to flow into post synaptic. That calcium if enough glutamate, will turn on genes, causes release of nitric oxide and causes more glutamate to be release. The more a glutamate neuron excites a post synaptic membrane- hebbian ltp (nootropics) things that help you learn (piracetam) does have an effect.
