PSC 101 Lecture 16: Psychopathology
Document Summary
Anxiety disorders 25% - phobia, panic ptsd. Mood disorder 19% - depression, bipolar. The heritability of depression is about 30-40% There is no one set of genetic variants that seems to be more in common in patients with. It has proven difficult to identify specific genes that mediate heritability depression compared to the general population. This is probably because there are multiple biological mechanisms. Common antidepressants such as monoamine oxidase inhibitors and selective serotonin reuptake inhibitors increase serotonin in the synapse. Time lag between changes in serotonin in synapse and therapeutic effect. Genetic variation in serotonin transporter associated with risk of depression. Short form of the promoter linked to reduced expression of serotonin transporter. Relationship between genotype and depression risk not found in all studies. Does not respond to at least six weeks of antidepressant medication (mao inhibitor or. Associated with increased risk for hospitalization, substance abuse, and suicide.
