MCDB 134 Lecture Notes - Lecture 12: Influenza A Virus Subtype H3N2, Influenza A Virus, Reoviridae
15 Nov 2017
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Influenza transmitted among human and animal in hong kong in 1968 with h3n2 glycoprotein. Slower than vsv and polio but more rapid than reovirus. The drug: amantadine hcl-> block m2 channel-> prevent acidification-> reduce the efficiency of infection. H7n9 (2013-2014) is sensitive to the blocking-> functional. 5"cap---(cellular b/c was stolen and acts as a primer)------- Uuuuu(stutter)--aaa virus cannibolize the cells message to make its own mrna. Pb2: cap-binding protein that binds cellular rna"s 5" cap. binds cap of cellular pre-mrna cellular pre-mrna. Pa: endonuclease. cleaves cell mrna 10-12nt. after cap. Pb1: catalyzes elongation. binds at the 5" region of the virion. 5" 7ch3 ga(x) agc---(pb1)---an5" everything before pb1 is cellular mrna doesn"t transcribe anything after u-stutters. 10-15 nucleotides off of cellular mrna, gets cleaved by pa, which turns into primer by pb1 (catalytic subunit), which catalyzed the elongation splice transcripts gives ns1, nep, m1, m2. occurs in the nucleus. Segment 7 includes m1 and m2, has splicing.
