MCDB 134 Lecture Notes - Lecture 18: Tumor Suppressor Gene, Carcinogenesis, Tata Box
15 Nov 2017
School
Department
Course
Professor
Document Summary
Has p97:major early promotor: active in nonterminal differential cells e6, e7, exp. Activity of e6 and e7 is driven by p97. P676: hpv16 (gives late gene product: l1, l2, e4) Hpv early genes expressed in nonproductive uninfected (transformed) cells and in productive infected cells (virus) regulatory proteins polyadenylation signals. E2: important for initiation of hpv dna replication precision. Binds ori, lcr, helicase, atpase transcription regulatory protein, works with cellular polymerase and general factors. works in dna replication represses e6 and e7. E4: targeted to cytoskeleton. alters the cytokeratins in infected cell. is expressed late. E5, e6, e7: plays roles in oncogenesis by blocking tumor suppressor (e6 blocks plays roles in oncogenesis by blocking tumor suppressor (e6 blocks. E5: alters membrane function targeted to plasma membrane of epithelial cell plays role in activation of epithelial growth factor receptor. Expressed in cytoplasmic then move back to nucleus. Require for transformation for cell gene products that are responsible for oncogenesis---> cervical carcinoma.
