MCDB 134 Lecture Notes - Lecture 24: Herpes Simplex Virus Protein Vmw65, Dna Virus, Primase
15 Nov 2017
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Cascade so there are 3 ways of genes expression. Are viral transcription factor activator (transactivators) virus: tf and transactivator cell: pol ii: polymerase to transcribe herpes genes in a regulated way (3 ways). uses tfii too. Allow the expression of beta gene products, which are important for nucleic acid (dna) synthesis and metabolism. Icp27 and 22: necessary to establish initial act of infection. Enzymes involved in nucleic acid synthesis that deals with metabolism. Viral dna polymerase (ul30), helicase, primase, ssdna bp. Are all targeted back to the nucleus and allow for replication to occur. Are the structural proteins: capsid and enveloped glycoproteins b/c there are lots of template, progeny virions require lots of these late products. Nucleocapsid proteins are targeted back to the nucleus to assemble the virion progeny. Structural proteins are targeted to either the nuclear membrane or the plasma membrane. Virion go through nuclear membrane-> er-> plasma membrane. Is episomal (replicate independently of host chromosomal dna)
