MCDB 134 Lecture Notes - Lecture 6: Vesicular Stomatitis Virus, Reoviridae, Animal Virus
15 Nov 2017
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Audio recording started: 10:03 am friday, april 14, 2017. Degradation of capsid and/ or removal of envelop. Can be complete or partial removal (led to activation vap) From ssrna to protein through translation using host machine. Strategies for expression of animal virus genomes aka. Genome is +/-dsdna -> +mrna i. ii. iii. iv. v. vi. 5" end of +ssrna is covalently linked to vpg" 3" end is linked to pa. Distinguished by genome, ph3 stability, serological, density of cscl. Both mice virus and are stable under acidic ph. Loss of vp4-> conformational change (esp. in vp1) Pentration receptor mediated endocytosis uncoating again within cell=complete, all capsid removed and +rna is released. Release of the genome +ssrna to the cytoplasm. ***bc it is +ssrna, it is already mrna so no transcription needed-> direct translation. A single open reading frame (orf), some utr (untranslationed region- long.
