MCDB 21 Lecture Notes - Lecture 8: T Helper Cell, Clonal Deletion, Cytotoxic T Cell

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Divided into cell mediated & humoral immunity. Cell mediated intracellular pathogens (viruses, bacteria, cancer) cytotoxic t cells = Humoral immunity extracellular pathogens (parasites & bacteria) b cells antibodies find pathogens and bind to it. Both are controlled by t helper cells (cd4) Without t helper cells there would be no specific immune system (wouldn"t be able to turn on) When activated they will differentiate into plasma cells (release thousands of antibodies per second) & memory b cells. B cells have antibodies on cell surface that are specific to b cells. All antibodies made from one b cell have the same specificity will only bind to one epitope. Plasma cells release granules full of antibodies. Why antibodies don"t attack your body"s proteins. Cells that recognize self antigens are killed off. Clonal deletion happens in the bone marrow. Those that survive recognize nonself antigens (pathogens) Travel and stay in the lymph node/spleen until one day they encounter their specific epitope.

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