BICD 100 Lecture Notes - Lecture 19: Transposable Element, Color Blindness, Transposase
29 Oct 2016
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Non-coding regions of the genome: transposons. Regulating gene expression: inhibiting translation, targeting mrna for degradation. Trna: translating the coding frame to aa sequence. *clicker: x-inactivation in eutherian mammals means genes on the x chromosome in females are functionally hemizygous like males. Color blindness is a x-linked recessive trait that mostly afflicts males. What is the implication of x-inactivation for colorblindness. Heterozygous females don"t display color blindness, so the gene must escape silencing. Dna break which meant this genotype turned into. Ds moved in and out of genes this turns out to be a transposon. Some somatic cells ds moves causing a dsb, and eliminating c", bz, allowing for color. Dna break to lose the other part of the chromosome. Not in germline, but in somatic cells. Transposons: a small piece of dna that can insert and extract itself in the genome. Transposase recognizes a short motif, extract everything between that motif.
