NTDT401 Lecture Notes - Lecture 23: Zinc Finger, Metallothionein, Macroglobulin
8 Dec 2016
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Active - regulated by gi mucosal cells absorption rate* ____ breaks down protein to make zn available. **1) absorbed by zip4 (most: absorbed by dmt1 (some, high intakes = absorbed between cells (paracellularly, feces = if bound to inhibitors. 3 fates of zn within the cell: used functionally, stored as part of metallothionein, transported - znt1 & albumin storage protein for zn metallothionein transport protein for zn. Amino acids main route of excretion feces! Functions*** (list: protein synthesis, cofactor for enzymes main form of zn for protein syntehsis zinc fingers zinc finger loop of aa where zn holds cys & his together role of zn in protein synthesis*** allows protein to fold! Shape is critical so we can get info from the gene to make a new cell/protein. Zn is used in the nucleus as a ___ transcription factor - regulaiton = turn on/off gene enzymes that zn acts as a cofactor for (6)***
