NEU 365W Lecture 15: 04_14 – Cannabinoids Pt 2
Document Summary
Endogenous vs exogenous cannabinoids: endogenous lipid molecules (resemble d9-thc that has a hydrocarbon tail, arachidonic acid (fatty acid) polyunsaturated & component of phospholipids in membranes. Anandamide (n-arachidonoylethanolamide) & 2-arachidonoylglycerol: both bind to cb1 receptor activation signaling cascades. Ex: gpcr (gi/o inhibitory alpha(i/o) & beta-gamma subunits. Alpha i/o inhibit ac less camp less pka. Less phosphorylation of many proteins (i. e. a-type k+ channel function increases = cell hyperpolarizes and become quiet) Beta-gamma regulated n & b/q-type voltage-gated ca2+ channel (inhibit) & enhance inwardly rectifying k+ channels. Not confirmed other effects: alpha i/o activate map kinase, beta-gamma inhibit na+ influx. Function of cb1 receptor = dampen the activity of presynaptic nerve endings and decrease nt release channel. Primary effect of the endogenous cannabinoids and thc: lipids synthesized on demand (short-half-life) Stimulus responsive lipid signals (1) anandamide formed by hydrolysis of n-arachidonoylethanolamide (n-arachidonoyl pe found in membrane) by phospholipase d in membrane.
