Global Health and Health Policy 50 Lecture 1: Antitubercular Drugs
2 Nov 2021
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Document Summary
Mycobacterium (mtb) infections: common infection sites, lung (primary site, brain (cerebral cortex, bone (growing end, liver less common, kidney less common, genitourinary tract less common. Diagnosis represents the chronic form of the disease. Bedaquiline (sirturo: 2013: food and drug administration granted accelerated approval, bedaquiline (sirturo) Inhibits mycobacterial adenosine triphosphate (atp) synthase: first drug in 40 years to treat tb with a new mechanism of action, side effects: headache, chest pain, nausea, qt prolongation. Inh: primary drug used: rifapentine, ethambutol rifabutin, pyrazinamide (pza) rifampin streptomycin. 2: type of infection, adequate dosing, sufficient duration of treatment, adherence to drug regimen, selection of an effective drug combination. Isoniazid: drug of choice for tb, resistant strains of mycobacterium emerging, metabolized in the liver through acetylation watch for slow acetylators , used alone or in combination with other drugs, contraindicated with liver disease. Inh: peripheral neuropathy, hepatotoxicity: rifampin: hepatitis; discoloration of urine, stools, and other body fluids.
