Problem 3. Explain why a protein involved in DNA repair would be considered a tumor suppressor. (10pts)
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Problem 4. PTEN is a phosphatase. What is the enzymatic function of a phosphatase?(8pts)
Problem 5. PTEN inhibits the EGFR pathway by inhibiting PI3K. Is PTEN a tumor suppressor or an oncogene? (8pts)
Problem 6. Explain loss of heterozygosity. Be sure to incorporate the concepts of germ line mutations and somatic mutations in your answer.(12pts)
Problem 7. A patient with Li-Fraumeni syndrome has a tumor with a mutation on only one allele of p53. Explain why this is not an example of loss of heterozygosity.(8pts)
Problem 8. A tumor virus produces a protein which inhibits p53. Is this viral protein an oncogene or a tumor suppressor? Why? (10pts)
Problem 9. Why might a tumor with mutations in p53 be resistant to radiation therapy? (8pts)
Problem 3. Explain why a protein involved in DNA repair would be considered a tumor suppressor. (10pts)
1
Problem 4. PTEN is a phosphatase. What is the enzymatic function of a phosphatase?(8pts)
Problem 5. PTEN inhibits the EGFR pathway by inhibiting PI3K. Is PTEN a tumor suppressor or an oncogene? (8pts)
Problem 6. Explain loss of heterozygosity. Be sure to incorporate the concepts of germ line mutations and somatic mutations in your answer.(12pts)
Problem 7. A patient with Li-Fraumeni syndrome has a tumor with a mutation on only one allele of p53. Explain why this is not an example of loss of heterozygosity.(8pts)
Problem 8. A tumor virus produces a protein which inhibits p53. Is this viral protein an oncogene or a tumor suppressor? Why? (10pts)
Problem 9. Why might a tumor with mutations in p53 be resistant to radiation therapy? (8pts)
