Pharmacology 2060A/B Study Guide - Midterm Guide: Lipid Bilayer, Sucrose, Cell Membrane
30 May 2016
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Document Summary
5 different types of drug molecules: polar, ions, qas, lipophilic molecules and ionizable molecules. Ay drugs with oh groups has increased water solubility. Water: covalent bonds between oxygen and hydrogen, share electrons, oxygen hogs the electrons, gives it a slightly negative charge to oxygen, no net charge, distributed unevenly. Ions have a net charge, blood full as ion, people supplement with calcium, magnesium, and we"ll learn about lithium. Net charge always positive, qas = central nitrogen bonded to 4 other groups, anything. Carbon and hydrogen, make these molecules soluble in lipids. Weak acids: ionized in basic/alkaline environments (high ph) Weak bases: ionized in acidic environments (low ph) Uncharged in environments that are like them, weak acid is ionized in a basic. I. e. stomach, urine (often) environment, and a weak base is ionized in an acidic environment. When a weak acid is in a base, it will change. All hydrophilic, cannot directly penetrate cell membrane because of high water solubility.
