NUSC 1165 Study Guide - Final Guide: Bariatric Surgery, Lorcaserin, Liraglutide
16 Dec 2018
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Document Summary
Every other chronic disease could use a medication besides obesity, but now there are more medications available. Medications: appetite control, fat malabsorption, gastric emptying. Decreasing absorption of fat in the gut. Slowing gastric emptying/ slowing motility of food in the gut. Problem with medications and diet: steatorrhea, things just sitting in the stomach. Most behavioral interventions are 10% weight loss. Trying to use this combo of meds and diet/lifestyle changes instead of surgery. Orlistat: inhibits gastric and pancreatic lipases so triglycerides from the diet are not hydrolyzed into absorbable free fatty acids, and instead are excreted unchanged. Lorcaserin: appears to promote satiety by activating anorexigenic neurons in the hypothalamus. Naltrexone-bupropion: appears to work on the hypothalamic melanocortin system and the mesolimbic reward system. Liraglutide- glp analogue: slows gastric emptying, increases satiety and decreases food reward. If there is a failure in lifestyle changes, then use pharmacology. Future: combination therapies and long term medications similar to diabetes management.
