MEDRADSC 3C03 Chapter Notes - Chapter 3-6: Nonsteroidal Anti-Inflammatory Drug, Cardiovascular Disease, Pharmacology

• School: McMaster University
• Department: Medical Radiation Sciences
• Course: MEDRADSC 3C03
• Professor: Meaghan Jefferson

Document Summary

Week 1 readings: chap 3, 4, 5, 6. Positive contrast agents: liquids containing iodine or gadolinium that have a greater attenuation than the patient"s soft tissue. Negative contrast agents: has a lower attenuation that the patient"s tissues; co2 is the only available option. Aim: adequately opacify the vessel but allow a level of grey-scale that allows branches/filling defects to be seen through the contrast - requires correct volume of cm. To achieve optimal opacification, bolus & timing of contrast is critical. 2 forms of reaction: direct effects & idiosyncratic responses: direct effects. Secondary to the osmolality & direct chemotoxicity of the contrast. Renal: contrast-induced acute kidney injury - rise in creatinine. Cardiac: m. c. during coronary angiography - usually manifest as arrhythmias or ischaemia; need to use non-ionic c+ in patients with ischaemic heart disease or heart failure. Haematological: uncommon; non-ionic iodinated c+ can induce clotting if mixed with blood - attention to catheter flushing.