PSYC62H3 Chapter Notes - Chapter 9: Receptor Antagonist, Insomnia, Nitric Oxide
Document Summary
Gamma-hydroxybutyrase (ghb): sodium oxybate (xyrem, nt and drug, cns depressant, schedule i drug, clinical: Cataplexy: a medical condition in which strong emotion or laughter causes a person to suffer sudden physical collapse though remaining conscious. Although prescribing a depressant to relieve daytime sleepiness seems paradoxical, ghb addresses some of the neuropathological features of narcolepsy, leading to a reduction in its symptoms: recreational: Obtain ghb either from illicit sources or by synthesizing ghb from gamma- butyrolactone (gbl). Gbl serves as an immediate precursor to ghb. Gbl serves as a prodrug by metabolically converting to ghb in the body: nefarious: In the body, naturally occurring ghb uses a metabolite of gaba. The metabolite process begins when the enzyme gaba transaminase converts gaba to its metabolite succinic semialdehyde. The enzyme succinic semialdehyde reductase transforms succinic semialdehyde to ghb. Gaba (gaba transaminase) succinic semialdehyde (ssa reductase) ghb. When 1, 4-butanediol enters the liver or the stomach, alcohol dehydrogenase converts 1, 4-butanediol to gbl.
