ZOO 3744 Chapter Notes - Chapter 3: Resting Potential, Vir Chakra, Extracellular Fluid

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23 Jul 2018
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K+ concentrated on inside, na+ and ca2+ concentrated outside: the importance of regulating the external potassium concentration. Potassium spatial buffering (astrocytes: equilibrium potential (eion, no net movement of ions when separated by a phospholipid membrane. Equilibrium reached when k channels inserted into the phospholipid bilayer. Electrical potential difference that exactly balances ionic concentration gradient. Membrane: ion channels and ion pumps create and maintain [] differences, na/k atpase and ca atpase pumps, 70% of atp used by the brain is used by na/k atpase. Ion movement: two forces: electrochemical driving force. Ion pumps create a concentration gradient across the membrane: electricity. Used to identify species that flowed during action potential. Shows that each channel is either in open or closed configuration with no intermediate. The sum of many recordings gives you the shape of sodium conductance: cast of chemicals, protein. Special transmembrane proteins: control resting and action potentials.

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