BIOL 1107 Chapter Notes - Chapter 20: Gene Therapy, Herbivore, Chromosome
Document Summary
Sec 20. 3: dideoxy sequencing - different type of sequencing strategy, ddntp = monomer for dna synthesis, terminates dna synthesis. After ddntp is added, no oh group is available on a 3" carbon to link the. 5" carbon on an incoming dntp monomer polymerization stops: ddntp forms fragments of different lengths depending on each base. Sec 20. 4: huntington"s disease, genetic disease that is passed onto generations, autosomal dominant disease, wanted to find the gene that codes for this trait, genetic map/linkage map - shows the relative positions of genes on the same chromosome. Site in dna that varies between alleles and at a single base pair: benefits of finding a diseased gene, improved understanding of the phenotype, therapy. Transgenic - modified allele engineering: animal model - using lab animals to compare diseases that are similar in both animals and humans, genetic testing.
