PHC320H1 Lecture Notes - Lecture 31: Geometric Standard Deviation, Tramadol, Corn Flakes
24 Mar 2015
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Plotting data we can use raw data by linear scale or probability plot or log-probabiltiy plot. Particle shape is another particle property that is important. Hpmc excipient used in broadly different dosage forms, then b is tramadol and c is nifedipine which are hypertensive drugs these 3 samples, difference is particle size difference, biggest at. Hpmc,then medium then small at nidefipine also shape is different, cellulose is a chemical reaction of cellulose to get this product so cellulose derivative, and tramadol hcl crystals and. We are interested in effect of shape, by particle shape, and know what properties will be influenced and how to characterize it. Difference between ratio and 1 increases then it means elongation increases, particles between less symmetric. This is the ideal case if we have a sphere. These 3 shape factors alphas, alphav, and their ratio are parameters describing deviation of particle shape from spheres. Particle density is defined as total weight/particle volume.
