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1. Why do cancer cells need to have lost both pRB and p53?

2. What is the evidence that enzymes whichmaintain the integrity of the genome are important in preventingcancer?

3. Why is Lossof Heterozygosity an important process in the development ofcancer?

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Lelia Lubowitz
Lelia LubowitzLv2
28 Sep 2019

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Related questions

1. What is heterozygosity? How does heterozygosity work and why it important in the body? Why is a loss of heterozygosity an important process in the development of cancer?

Problem 7. A patient with Li-Fraumeni syndrome has a tumor with a mutation on only one allele of p53. Explain why this is not an example of loss of heterozygosity.(8pts)

Problem 8. A tumor virus produces a protein which inhibits p53. Is this viral protein an oncogene or a tumor suppressor? Why? (10pts)

Problem 9. Why might a tumor with mutations in p53 be resistant to radiation therapy? (8pts)

2

Problem 10. Create a molecular diagram using this information: Double stranded DNA breaks activate ATM. ATM phosphorylates p53. When p53 is phosphorylated, it can travel to the nucleus and act as a transcription factor-to increase the expression of a protein called BAX. BAX is a protein that turns on apoptosis. Your answer should contain the components of this pathway (e.g. double stranded breaks, ATM, p53, BAX, Apoptosis, Cancer) and activate or inhibit signs (you can use words if you dont want to draw symbols). (16pts)

Problem 3. Explain why a protein involved in DNA repair would be considered a tumor suppressor. (10pts)

1

Problem 4. PTEN is a phosphatase. What is the enzymatic function of a phosphatase?(8pts)

Problem 5. PTEN inhibits the EGFR pathway by inhibiting PI3K. Is PTEN a tumor suppressor or an oncogene? (8pts)

Problem 6. Explain loss of heterozygosity. Be sure to incorporate the concepts of germ line mutations and somatic mutations in your answer.(12pts)

Problem 7. A patient with Li-Fraumeni syndrome has a tumor with a mutation on only one allele of p53. Explain why this is not an example of loss of heterozygosity.(8pts)

Problem 8. A tumor virus produces a protein which inhibits p53. Is this viral protein an oncogene or a tumor suppressor? Why? (10pts)

Problem 9. Why might a tumor with mutations in p53 be resistant to radiation therapy? (8pts)


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