BIOL125 Lecture Notes - Lecture 4: Lipid Bilayer, Semipermeable Membrane, Extracellular Fluid

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Diffusion and Osmosis
1.13. Definitions related to movement of molecules
o 1.13.1. semipermeable membrane
Must be lipid soluble
Only small, uncharged molecules or larger lip-soluble molecules can
diffuse freely across the phospholipid bilayer
If impermeable no molecule could cross membrane
If freely permeable any molecule could pass across membrane
Movement of molecules based on
Lipid solubility
Electrical charge
Size
Molecule (3D) shape
Movement may be active (requires energy in the form of ATP) or passive (no
energy expenditure)
Benefits
Small uncharged molecules e.g. O2 and CO2 passively diffuse (down the
concentration gradient) across the phospholipid bilayer
Small charged molecules move down their concentration gradient and
diffuse across membranes through channels with no energy
expenditure
Proteins e.g. enzymes and structural proteins stay in cells as they are
too big to cross
Disadvantage - cells must expend energy ATP in active transport process e.g.
to pump molecules against their concentration gradient, or export wastes via
exocytosis
o 1.13.2. solute
Body contains a large percentage of water: interstitial fluid (ISF), blood, lymph
and cytoplasm
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