BIOL30001 Lecture Notes - Lecture 22: Scrotum, Leydig Cell, Sertoli Cell
13 Aug 2018
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Document Summary
Sexual differentiation the determination how the gonad makes the decision. What the genes and mechanisms are in place. In mammals male and female embryos initially look alike. We have xy sex determination a single gene on the y chromosome. Sry is a master regulator that triggers the development of the gonad primary target is sox9 which is the primary conserved factor that switches on everything else in the development of the testes. Sox9 is enough to drive development without the sry gene at all up regulation of sox 9 therefore can allow for disorders. Sox 9 shuts down female development early gonadal structure this is early if you have sry then the cells will follow the testicular fate. Waiting for hormonal ques trhough the mesenephrous the md outside. We understand so much now that hormones help pattern the brain and the the brain is different in males and females they are wired differently controversial topic connections.
