BIOL30001 Lecture Notes - Lecture 7: Prolactin, Adrenarche, Sweat Gland

• School: University of Melbourne
• Department: Biology
• Course: BIOL30001
• Professor: Mark Green

Document Summary

Maturation of cns: shown by studies in other species (higher primates) , induction of gonadotrophin pulses in immature pre- pubertal rhesus monkey by hourly gnrh pulses over. Increased sensitivity of gonads to fsh and lh. Increased production of gondola steroids, e2, t, p4. Increased response of cns to steroids maturation, self-perpetuating. Kisspeptin: discovered to regulate hpg axis in 2003, various peptides derived from a 145 a. a. protein encoded by kiss1gene, found in hypothalamus, act via g-protein coupled receptor kiss1r (gpr54, kiss1r found on gnrhneurons, exogenous kisspeptin stimulates. Gnrhsecretion: mice with disrupted kiss1or kiss1r prevents puberty, onset of kiss1expression in hypothalamus and increased kiss1r in gnrh neurons just before puberty, administration of kisspeptin to prepubertal rats advances onset of puberty. In both male and female, re-activation of hpg axis: Increased gnrh pulses rst start at night, heralds pubertal onset, then continue dduring the day. In response, lh level is increased, in mid-late pubertal time, lh level is higher than in adult.