BIOM20001 Lecture 36: 36 Integrating cells into tissues II anchoring cell junctions B
Document Summary
Clusters of integrins permit ecm signals to be transmitted but integrins have no kinase domains. Signalling events require other kinases. e. g. the main one is focal adhesion kinase (fak) Integrins may act as mechanoreceptors - senses stress. Tension on the cytoskeleton may combine with growth factor signaling to promote g1 progression. Take slide and add a single large spot of fibronectin (a key component of ecm) Spot out the same amount of fibronectin but as tiny little spots. As long as a cell could cover the fibronectin patches it would make the same number of linkages with ecm. Thus there would be the same amount of signaling. The latter cell spreads out and grows because it is under mechanical stress. This stress on cytoskeleton required to promote correct signaling. Cell requires some stress in order to survive. 3 1, 6 4 integrins in hemi-desmosomes adhere cells to the basement membrane. Failure of keratinocytes to adhere to basement membrane.
