BIOM20001 Lecture Notes - Lecture 47: Chloramphenicol, Enterococcus, Aminoglycoside
Document Summary
Bacteria has d amino acids in cell wall. Alternating d and l in cell wall makes it rigid so molecules can"t fold. The pentapeptide that links chains is made of 5 glycines. Connected from the l-lys to d- ala of the pentapeptide. Becomes immobilised on inner aspect of plasma membrane. When complete building block transported to exterior aspect of membrane. Note: the pplipid the pyrophosphate lipid carries the glc-nac-mur. nac disaccharide inside the cell, binds on the inner cytoplasmic membrane. In the precursor building block there are two d-ala in the final product (product inserted into the cell wall) there is only one. Pentaglycine is put on all inside the cell - building block. The building blocks are put together outside the cell, shoved inside the wall - bond forms between the two polysaccharides and a peptide bond. Transpeptidases link the glycine from the pentapeptide to another d-ala. aka penicillin- binding proteins (target of penicillin)
