BIOM20001 Lecture Notes - Lecture 52: Digestion, Microorganism, Mast Cell
Document Summary
Nod- like receptors (nlr) exist in the cytoplasm; detect degraded gram -ve peptidoglycans. Tlr 3,7,9 detect microbial derived nucleic acids - recognise cpgdna/ssrna/dsrna. Important receptors of microbial and viral nucleic acids. Tlr2 forms a heterodimer with tlr 1 or tlr 6. Dectin-1 and mannose receptors bind to sugars in the cell wall. Outcomes of prr-pamp ligation vary, depending on the receptor and its location. Ligation of soluble receptors (eg mbl) phagocytosis. Ligation of cell bound receptors such as the mannose receptor, scavenger receptors phagocytosis. Ligation of tlrs and nods may result in expression of different cell surface receptors. So, activation has different outcomes a protein secreted by cells that interacts with and affects the behaviour of nearby cell bearing the appropriate receptors. Affect multiple functions (regulate innate immunity, adaptive immunity, haematopoiesis and more) Multiple names interleukins (il-), interferons (ifn-), colony stimulating factors (csf"s)- stimulate maturation of immune cells from the bone marrow, tumor necrosis factors (tnf"s)
