BIOM20001 Lecture Notes - Lecture 65: Peptic Ulcer, Atherosclerosis, Macrophage
Document Summary
Persistent stimulus - cycle of macrophages and lymphocytes - inflammation, injury (to cells), healing (scar tissue) Can see much scar tissue (healing) and lymphocytes. We see healing in form of collagen rich scar tissue. You will draw on some of your previous lectures: acute inflammation, healing, immune-mediated injury, microbiology. Chronic goes on for a long time. Ge(cid:374)erally (cid:271)e(cid:272)ause the offe(cid:374)di(cid:374)g age(cid:374)t (cid:272)a(cid:374)(cid:859)t (cid:271)e (cid:272)leared. Too tough: e. g. tb is waxy so very hard to kill. Hashi(cid:373)oto(cid:859)s thyroiditis, croh(cid:374) disease, hepatitis, (cid:272)hro(cid:374)i(cid:272) a(cid:271)s(cid:272)ess, fi(cid:271)roti(cid:272) lu(cid:374)g disease, multiple sclerosis. Possi(cid:271)ly e(cid:448)e(cid:374) atheros(cid:272)lerosis (cid:894)(cid:373)yo(cid:272)ardi(cid:374)al i(cid:374)far(cid:272)tio(cid:374), stroke, et(cid:272)(cid:895), alzhei(cid:373)er(cid:859)s dementia, cancer and diabetes. Not simply the same as acute inflammation which has gone on for a long time. There are macrophages and t cells inducing each other by secreting cytokines. Eg. granulomas, epithelioid macrophage, multinucleate giant cells, necrosis. There is ongoing tissue destruction and fibrosis (unlike in acute inflammation), generally as a result of the chronic inflammation.
