BIOM20002 Lecture Notes - Lecture 4: Cyclooxygenase, Cortisol, Insulin

• School: University of Melbourne
• Department: Biomedicine
• Course: BIOM20002
• Professor: All

Document Summary

Drug natural or synthetic substance that affects biological function or structure when administered to the human body. Pharmacogenomics individual drug response determined by phenotypes. Pharmacokinetics what the body does to a drug (absorption/distribution/metabolism) Pharmacodynamics what a drug does to the body (biological response) Can either be an endogenous or synthetic compound. To form specific types of bonding to trigger cellular functions. After oral administration, many drugs (morphine, pentazocine) are absorbed intact from the small intestine and transported first via the portal system to the liver, where they undergo extensive metabolism. Used to replace damaged arteries that supply blood to the heart by arteries from another area of the body. Central compartment represents central blood, brain and liver that receive high proportion of cardiac output; propofol is determined by rate of infusion, redistribution to secondary compartments and hepatic clearance. Competitive antagonist which binds to nicotinic receptors and blocks the proper binding between acetylcholine and receptors.