BIOM20002 Lecture Notes - Lecture 28: Tyrosine, Cortisol, Aspirin
Document Summary
28 drugs: what you need to know and why. Drug: a chemical substance of known structure, other than a nutrient or an essential dietary ingredient, which, when administered to a living organism, produces a biological effect e. g. caffeine, ethanol, atenolol, d-tubocurarine, erthropoietin, fomivirsen, mipomersen. Use of antisense oligonucleotides as drugs is limited because it is hard to get into cells cos it is highly charged. Cardiovas(cid:272)ular syste(cid:373) (cid:894) a(cid:374)d adre(cid:374)o(cid:272)eptors; drug distri(cid:271)utio(cid:374)(cid:895) Lung volumes & respiratory mechanics (adrenoceptor agonist bronchodilators). Can start with the molecule and gradually learn more about it up to the level of the population drugs act on cells/tissues to elicit therapeutic, desired, adverse and toxic effects. Pharmacodynamics - actions of the drug on the body. Pharmacokinetics - actions of the body on the drug. Transmission (release of molecules), reception (by membrane bound receptors. Ligands can be free or bound to cells), response.
