BIOM20002 Lecture 56: 56 Applied Cardiovascular AnatPhys 2 A
Document Summary
Getting oxygen to the tissues: what matters to an anesthetist. O2 flux = o2 content of blood x cardiac output. O2 dissolved in plasma, o2 attached to haemoglobin. Oxygen used = oxygen flux x extraction (extraction is normally about 25%, differs by tissue) Oxygen flux = hb x saturation x cardiac output = hb x satn. x c. o. Hb normal 130-170 g/l male 120-150 g/l female. Erythropoetin (epo) is produced in kidneys in response to hypoxia, exercise, altitude. 1-2 % of population has iron deficiency anaemia (anaemia: abnormally low level of. 11% of females are iron deficient (not anaemic) Interferes with ability to manufacture hb to replace lost blood. Hb can carry 1. 34 mls o2/g hb, normal hb is ~130-170g/l of blood in adult male. If hb is 145 g/l, 145 x 1. 34 = 194 ml/l. Solubility of o2 in plasma is 0. 03mls/mmhg/litre - 3 mls/l at 1 atm. Normal blood can carry about 200 mls o2/litre.
