BIOM20002 Lecture Notes - Lecture 61: Nephron, Reabsorption, Creatinine
Document Summary
H+ (causes acidosis), creatinine (from muscle metabolism and a marker of kidney function) and urea (product of protein metabolism. Makes you uremic) are waste produces in urine. Liver deals with excretion of lipid soluble stuff. Not interstitial fluid because this is not in blood. To make 2l of urine you need 200l of plasma to pass through kidneys. Waste products normally at low conc in blood. Urine versus blood - concentrations under normal conditions and steady water intake. Note that waste product is more conc in urine than plasma. Can achieve higher conc by reabsorbing fluid from filtered fluid. Low conc of these are achieved by say metabolising them, reabsorbing them, block them from entering urine. In bowman"s capsule there is an afferent (pre-glomerular) and efferent (post-glomerular) arterioles. Smooth muscle in their walls for constriction/dilation to regulate flow. Reabsorption occurs all the way along (in particular the last reabsorption of water)
