BIOM30001 Lecture Notes - Lecture 13: Subventricular Zone, Paneth Cell, Goblet Cell
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Occurs in subventricular zone and hippocampus
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New neurons from the SVZ wind up in the olfactory epithelium
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Hippocampal neurogenesis may have a role in learning and memory
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Goblet cells: secrete mucus
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Enteroendocrine cells: secrete gut hormones
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Paneth cells: innate immunity - produce defensins and lysozyme
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Enterocytes: absorb
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Crypt is microenvironment. All come from one stem cell
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The four types of differentiated cell in the adult gut are formed constantly from stem cells in
the crypts
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Renewing cell populations and extrinsic control of growth and differentiation: Gut and hair
follicle
Frontiers Page 6
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Extrinsic signals and networks of transcription factors regulate gut cell differentiation
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Extrinsic signals involved in regulation of stem cell growth and differentiation in the hair
follicle
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Frontiers Page 7
Document Summary
New neurons from the svz wind up in the olfactory epithelium. Hippocampal neurogenesis may have a role in learning and memory. Renewing cell populations and extrinsic control of growth and differentiation: gut and hair follicle. The four types of differentiated cell in the adult gut are formed constantly from stem cells in the crypts. Paneth cells: innate immunity - produce defensins and lysozyme. Extrinsic signals and networks of transcription factors regulate gut cell differentiation. Extrinsic signals involved in regulation of stem cell growth and differentiation in the hair follicle. Extrinsic signaling from surrounding cells regulates stem cell proliferation. Regulatory cells surrounding stem cells in niche regulate their behaviour - keep them quiescent or activate them. Quiescent stem cells that are not dividing (or very slowly dividing) represent a tissue reserve (at top of hierarchy) that is activated only during damage. Transit amplifying cells are the ones that start to divide more.
