BIOM30001 Lecture Notes - Lecture 33: Narcolepsy, Cataplexy, Orexin
Document Summary
These animals go from being awake straight to rem sleep, like people who suffer from narcolepsy with cataplexy. Transition from wake to rem is triggered by emotions e. g. dogs who fall asleep when given food, or kids who lose muscle tone when told a joke. Orexin peptides are absent in narcoleptic human brain. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. No orexin in people with narcolepsy or in cataplectic patients in brain or csf. The narcoleptic / cataplectic phenotype seen human narcolepsy is recapitulated in orexin peptide ko and ox1/ox2 receptor ko mice . Narcolepsy/cataplexy (arrows ) is commonly seen in orexin ko mice, narcoleptic dogs (defect in ox2r) and narcoleptic humans with cataplexy (absence of orexin in. Wt: periods of wake and sleep which are well distributed. Ko animals shifts back and forth whether day or night.
