BIOM30001 Lecture Notes - Lecture 36: Academic Emergency Medicine, Opioid Use Disorder, Pethidine
Document Summary
Opioid (codeine) in combination with analgesics increases paracetamol/ibuprofen toxic exposure risk. *heard, k otc abuse common in ed acad emerg med conf:2005; robinson g et al. Misuse otc codeine-containing analgesics nzmj vol 123 june 2010. Serious morbidity assoc misuse otc codeine-ibuprofen mja vol 193 (5) sept 2010. ****macdonald, n; macleod, s has time come to phase out codeine? cmaj 2010 doi. Paracetamol/acetaminophen commonest cause acute liver failure in usa. Multicentre, prospective study: larson, a et al in hepatology 2005: 42, pp 1364-1372. *madadi p, ross cj, hayden mr, et al. Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case control study. clin. ** voronov p, przybylo hj, jagannathan n. apnea in a child after oral codeine: a genetic variant an ultrarapid metabolizer. *** ciszkowski c, madadi p, phillips ms, et al. Ort: opioid replacement treatment (also matod) (agonist/ "maintenance" therapy)
