MIIM20002 Lecture Notes - Lecture 28: Transposable Element, Chromosome, Vancomycin
4 Aug 2018
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Tn1549 transposon has vanb locus containing 7 genes. Transmission model a: patient arrives in hospital carrying vre and spreads bacteria to surrounding environment control strategy. Screen patients for vre on arrival in hospital. Ensure staff follow hand-hygiene protocols, wear approved protective clothing, and that cleaning of hospital equipment and the hospital environment is optimal. Expected outcomes of interventions based on model a. If the number of newly colonized patients (cross-transmission) can be reduced, natural attrition of colonised patients (death or discharge) will progressively eliminate vre from the hospital. Measure cases of vre at hospital, intervene, remeasure to see effect - But vre went up vanb carried in anaerobic gut commensals in over 50% of people. So there is a reservoir of transposon that carries vancomycin resistance in people outside the hospital. Inject in mice our normal microflora + vse and you can get vre.
