NEUR30002 Lecture Notes - Lecture 14: Munc-18, Membrane Protein, Endocytosis

• School: University of Melbourne
• Department: Neuroscience
• Course: NEUR30002
• Professor: Angelina Fong

Document Summary

* there is a process of exocytosis where the contents of the vesicle are emptied into the synaptic cleft. * the(cid:396)e"s o(cid:374)e to o(cid:374)e t(cid:396)a(cid:374)s(cid:373)ission in mammalian nmjs and this is because there is a large number of vesicles being released because there is a large number of release sites/active sites. A synapse can just have one release site as many synapses in the cns do or it can have 300 release sites as in the frog nmj does. * in the frog nmj, there are 300 active zones per synapse. * mammalian nmjs typically have 10-100 release sites/active zones. * many hippocampal & neocortical synapses (in the cns) consist of a single active zone. * the sy(cid:374)apti(cid:272) (cid:862)u(cid:374)it(cid:863) is the a(cid:272)ti(cid:448)e zo(cid:374)e. A widened, electron-dense intercellular space (a synaptic clef), typically 20-50nm. A post-synaptic density (psd), rich in protein.