PHYS20009 Lecture Notes - Lecture 3: Naked Mole-Rat, Giant Squid, Drosophila Melanogaster
1 Feb 2020
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Model systems: experimentally test particular questions, species of animal or type of preparations. Well-designed models can help determine: site of action or, levels of control in a system. Consider these factors: genetics, anatomical structures, physiological mechanisms. Other factors: practicality of model, availability, housing, cost of maintaining the animals, ethics, disease progression and genetics. Human to mouse 90. 0% could be aligned with human genome 99% mouse genes have human analogues. Human to fly 60% similarity 77% of known human disease genes with recognizable match. Analogous genes = analogous proteins possibly similar function: eg. Neurotransmitter ach, signaling molecules camkii and pka are important for memory formation are found in mammals and insects. Some animals are chosen because of how fast they reproduce eg. flies reproduce much faster than humans. Giant squid axon (giant axon of squid) Best is to use the naked mole rat (longest living rodent in the world 30+ years)
