PHYS20009 Lecture Notes - Lecture 6: Tidal Volume, Cellular Respiration, Blood Gas Tension
1 Feb 2020
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Ventilation: oxygen moving from environment into blood. Inspiration and expiration: measured by tidal volume, respiratory frequency. Pulmonary diffusion: gas passes pulmonary diffusion barrier. Tissue diffusion: getting from blood to tissues. Respiratory and cardiovascular system must work closely together to maintain supply of oxygen for tissue and cellular metabolism. Pao2 partial pressure of oxygen in artery. Effect of hypoxia (deprived of oxygen supply at tissue level) Frequency rate shoots up and then decreased during hypoxia: tidal volume still increasing overall minute ventilation is sufficient, co2 levels decrease as you hyperventilate, due to fall in co2 because of hyperventilation. Ab muscles recruited when forcing the expiration: eg. exercise, similar effect central chemoreceptors, sense co2, brainstem. Peripheral chemoreceptors: sense primarily o2 and ph, carotid and aortic bodies. Both increase activity pha = ph of arteriole hypo = low; ox = oxygen emia of the blood.
