PHYS30005 Lecture Notes - Lecture 30: Cellular Differentiation, Histone Deacetylase, Transferase

• School: University of Melbourne
• Department: Physiology
• Course: PHYS30005
• Professor: Professor

Document Summary

Lecture 30: transcriptional regulation of skeletal muscle stem cells. Mitochondria: powerhouse of the cell production of atp. Quiescent state exist outside of cell cycle and express high levels of pax7 & don"t express myod. Image on right: simple transverse section of mouse skeletal muscle: red: capillaries that feed the muscle colocalization b/w satellite cell and capillary -> cell can receive signals from systemic environment & ready access to supply of oxygen. Myod regulates the initial commitment to myogenic lineage (to become myoblast) When cell exits cell and starts to express. How are certain genes turned on or. Binding of transcription factors to the 5" promoter region. Binding of rna polymerase (rna pol ii) to the. Epigenetics: a heritable change in the absence of change in the dna sequence: modification sitting on top of the dna, modification to histones. Histone: 4 core proteins that dna wraps around.