PSY2061 Lecture Notes - Lecture 8: Theodor Meynert, Anterograde Amnesia, Pseudobulbar Affect
1 Jun 2018
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Lecture 8 continued
Amnesia
-A condition in which one’s memory is lost
-a number of different causes of amnesia
-Anterograde amnesia loss of long term memory
-Retrograde - loss of pre-existing memories to conscious recollection, beyond an
ordinary degree of forgetfulness. Targets patients most recent memories. Amount of
memory lost depends on severity of the case
Amnesia of Alzheimer’s disease
Brain atrophy in Alzheimer’s disease
-The cerebral cortex of an Alzheimer’s patients has gyri that are clearly shrunken in
comparison with normal person
-Volumetric brain imaging often shows thin cortical gyri, enlarged sulci and ventricles,
and a reduced metabolism in patients with Alzheimer’s disease (AD). AD group has
reduced bilateral activation in prefrontal, parietal, temporal, and posterior cingulate (PC)
regions
Alzheimer’s disease
early symptoms:
-forgetfulness
-impaired recent memory
-transient confusion, anomia, disorientation, confabulation, and anosmia
-followed by: deficits in general cognitive functioning
-performance of concurrent tasks also impaired (frontal component)!
!
Later symptoms:
-repetitions.
-apathetic,
- careless with appearance and hygiene,
-emotional lability,
-indifference,
-restlessness,
-agitation,
-impatience,
-disinhibition,
-pessimism,
-aggression
-True aphasia, agnosia and apraxia, and the motor disorders come later
Document Summary
A condition in which one"s memory is lost. A number of different causes of amnesia. Anterograde amnesia loss of long term memory. Retrograde - loss of pre-existing memories to conscious recollection, beyond an ordinary degree of forgetfulness. Amount of memory lost depends on severity of the case. The cerebral cortex of an alzheimer"s patients has gyri that are clearly shrunken in comparison with normal person. Volumetric brain imaging often shows thin cortical gyri, enlarged sulci and ventricles, and a reduced metabolism in patients with alzheimer"s disease (ad). Ad group has reduced bilateral activation in prefrontal, parietal, temporal, and posterior cingulate (pc) regions. Transient confusion, anomia, disorientation, confabulation, and anosmia. Followed by: de cits in general cognitive functioning. Performance of concurrent tasks also impaired (frontal component) True aphasia, agnosia and apraxia, and the motor disorders come later. Eventually patient becomes bed-ridden, mute and unresponsive. Memory loss more profound and deterioration more rapid than in normal ageing.
