BIOL3006 Lecture Notes - Lecture 2: Rcc1, Guanine, Cytosol
Document Summary
Process by which nuclear and cytoplasmic components of cells are divided in two. Two processes: mitosis, genomic and non-genomic contents are duplicated and segregated. Including cytoplasm and membrane (important for asymmetric cell division where two progenies have different cell fates: daughter cells are genetically identical, meiosis, associated with sexual reproduction, daughter cells are genetically distinct. Chromosome segregation and mitotic spindle: during s phase, duplicated chromosomes remain attached to one another, proper segregation of chromosomes is important as each cell needs a complete set, the mitotic spindle ensures this process occurs correctly. Spindle organisation: spindle poles, microtubule organising centers (mtocs, composed of centrosomes, kinetochore mts. Mt formation: eg. polymerases, therefore, due to the spatial separation between rcc1 in the nucleus (near chromosomes) which activates ran, and rangap in the cytosol which inactivates ran, a gradient exists. Mt based assembly: capacity to self-assemble (+) ends tend to polymerise, augmented by proteins (augmin)
