MICR3002 Lecture Notes - Lecture 4: Mutation, Reassortment, Antigenic Shift
Document Summary
The result of ifn signalling is the production of antiviral factors (isgs) Isgs interfere with different stages on virus replication. Evasion strategy 1: viral proteins interfere with ifn signalling pathway. Evasion strategy 2: viral proteins bind to viral dsdna so isgs cannot recognise them, many viruses to do this to ensure avoidance. Evasion strategy 3: methylation of viral rna cap to avoid recognition by isg (ifit1, can use host methylation machinery. Viruses can also attempt to inhibit the activity of isgs after they are produced. Triggering the adaptive immune response requires professional apcs (such as dendritic cells) Once activated by local infection, dcs migrate to the lymph nodes to present ags to na ve t cells. Na ve t cells proliferate into cd4 and cd8 t cells that differentiate into helper (for b cells to make ab) and effector (cytotoxic) cells.
