PHRM3021 Lecture Notes - Lecture 16: Carboxymethyl Cellulose, Methyl Cellulose, Artificial Skin
Document Summary
Collagen brous protein, approx 60% of total protein content of mammals. Four structural levels: protein chain (alpha chain) approx 1000 amino acid, collagen molecule 3 protein chains intertwine forming a triple helix, fibrils packaging of collagen molecules, collagen fibres association of fibrils. At temperatures >40 degrees, fibrous collagen loses the ordered triple helix structure, forming a random coil conformation. Applications: artificial skin treatment of burns injuries, diabetic ulcers. Biodegradable scaffold for fibroblasts and keratinocytes: cosmetic surgery collagen injected into dermis, resorbable sutures (discontinued, controlled release membrane for eye medication e. g. pilocarpine. Obtained by partial hydrolysis (chemical or enzymatic) of animal collagenous tissues, tendons, skins, ligaments, bones (partially hydrolysed collagen) Type a prep under acidic condi(cid:415)ons (ph 7-9) Type b prep under alkaline conditions (ph 5) Disadvantage leaching of cytotoxic glutaraldehyde monomers from the gela(cid:415)n matrix in vivo. _______________________: properties and applications of methyl cellulose:
