PHRM4012 Lecture Notes - Lecture 1: Monoamine Oxidase B, Palpitations, Iron-Deficiency Anemia
25 Jul 2018
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Serum ferritin iron stores (can be normal even in infection, elderly, hepatic) Counselling ferrograd 325mg = 105mg: take with food stomach upset/nausea/vomiting, needs acidic environment ppi, mylanta, calcium, treat for 3-6 months monitor levels. Domperidone peripherap dopamine-antagonist parkinson"s disease: se qt interval prolongation. Metaclopramide dopamine-antagonist: use for 5 days max, se epses (<20 years old or elderly), opposite. Prochlorperazine dopamine-antagonist: se epses more than any other, anticholinergic. Ondansetron 5ht antagonist: epses, seizures, constipation. Tardive dyskinesia involuntary muscle movements slow/slow onset face and jaw. Comorbidities: psychosis, depression, orthostatic hypotension, constipation. Levodopa/da agonist se nausea/vomiting for initial treatment domperidone 30 mins before dose. Maoi tyramine-rich foods cause hypertension, palpitations fermented food. Cheese, wine, soy sauce avoid during and 2 weeks after treatment. Mao-b inhibitors inhibit breakdown of mono-amine oxidase b (adrenaline, noradrenaline, dopamine, serotonin) less tyramine se: no trials to compare efficacy of rasagiline vs selegiline. Ssri/snri/tcas/opioids, st john"s wort serotonin toxicity.
