PHRM4012 Lecture Notes - Lecture 2: Pindolol, Hyperthyroidism, Sleep Apnea

• School: UQ
• Department: Pharmacy
• Course: PHRM4012
• Professor: Associate Professor Neil Cottrell

Document Summary

Heart failure: acei, bb bisoprolol, carvedilol, metoprolol. Acei inhibitor angiotension i conversion to angiotension ii + inhibit bradykinin breakdown inhibits angii-induced sodium retention/vasoconstriction/aldosterone release + dilation of efferent arterioles. Se angiodema, hypotension, hyperkalaemia, headache, renal impairment (cease if change >30% in first 2 months) Dpp4i (-gliptins) increased risk of angiodema. May cause dizziness so careful when getting up. Arbs inhibit angiotensin i conversion to angiotensin ii inhibits. Angii-induced sodium retention/vasoconstriction/aldosterone release + dilation of efferent arterioles. Angiodema cross sensitivity with acei ~10% Bb inhibits beta-r vasodilation/reduce cardiac contractility/heart rate/bronchoconstriction. Second line heart failure/other drugs not tolerated increased cardiovascular risk. Se fatigue, masking of hypos, bronchospasm, orthostatic hypotension. Don"t stop take abruptly rebound tachycardia wean off over 2 weeks. Se orthostatic hypotension, constipation, peripheral oedema, flushing, bradycardia. Thiazide diuretics inhibit sodium reabsorption in distal tubule increase sodium/potassium excretion first line in elderly patients >65 years. Methyldopa/clonidine a2 receptor agonist on presynaptic neuron.