BIOL1006 Lecture Notes - Lecture 8: Dna Replication, Semiconservative Replication, Heredity

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Lecture 8- Molecular Basis of
Iheritace & the Cetral Doga
Living Cells
Have fundamental similarities
- DNA
- RNA
- Proteins
Strong evidence for LUCA (single origin of life)
Genome: complete DNA sequence of an organism
Discovering DNA’S Structure
A+T
C+G
= DNA just right
DNA structure has novel features that are considerable biological interest
Replicate
Self repair
Hold information
DNA Replication
DNA Replication is semi-conservative
Semi Conservative: always a parent strand in the double daughter helix
DNA Can Self Repair
Mistakes in DNA sequence is costly
DNA polymerases proofread and repair
Other repair mechanisms distinguish new strands from template strand
and repair
Very accurate
Still enough raw material for evolution
DNA can hold information
Encoded using nucleotide sequence
- Organisms differ due to different sequences
Complementarity (A-T, G-C) allows copying and repair
A mechanism for heredity, organisms can pass their genomes
DNA Encodes Biological Difference
Biological features of different animals
Figure out when social living evolved in an animal
DNA Packaging
Packaged in our cells
Gene is instruction to make a protein in the cell
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