BIOL1006 Lecture Notes - Lecture 8: Dna Replication, Semiconservative Replication, Heredity
9 Jun 2018
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Lecture 8- Molecular Basis of
Iheritace & the Cetral Doga
Living Cells
• Have fundamental similarities
- DNA
- RNA
- Proteins
• Strong evidence for LUCA (single origin of life)
• Genome: complete DNA sequence of an organism
Discovering DNA’S Structure
• A+T
• C+G
• = DNA just right
• DNA structure has novel features that are considerable biological interest
• Replicate
• Self repair
• Hold information
DNA Replication
• DNA Replication is semi-conservative
• Semi Conservative: always a parent strand in the double daughter helix
DNA Can Self Repair
• Mistakes in DNA sequence is costly
• DNA polymerases proofread and repair
• Other repair mechanisms distinguish new strands from template strand
and repair
• Very accurate
• Still enough raw material for evolution
DNA can hold information
• Encoded using nucleotide sequence
- Organisms differ due to different sequences
• Complementarity (A-T, G-C) allows copying and repair
• A mechanism for heredity, organisms can pass their genomes
DNA Encodes Biological Difference
• Biological features of different animals
• Figure out when social living evolved in an animal
DNA Packaging
• Packaged in our cells
• Gene is instruction to make a protein in the cell
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