EXSS3037 Lecture Notes - Lecture 15: Rhabdomyolysis, Dementia, Cumulative Incidence
22 Aug 2018
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Lipid lowering drugs: lecture 7b: drugs to treat hyperlipidaemia, hdl drives total cholesterol, don"t immediately put on medication, address lifestyle factors first, try to change in 3-6months. If low risk, then lifestyle modification is the primary treatment. Managing lipids according to cv risk: low: lifestyle modification/management, mod high: start medication, other reasons to start meds, diabetes & indigenous population, family history of chd, mod risk + family chd history or metabolic syndrome. Target lipid levels: ldl-c = <2. 5mmol/l (no cvd) or 2mmol/l (w/ cvd, hdl-c = >1mmol/l, tg = < 1. 5mmol/l. Lipoproteins: cholesterol & tg transported in plasma as lipoproteins, cholymicrons, vldl, ldl, hdl. Insomnia: stomach cramps or pain, constipation, rash, diarrhea, nausea, headache, tiredness, dizziness. Scandanavian simvastatin survival study, 1994: patients with ihd & cholesterol 5. 5-8 mmo/l, ldl-c reduced 35%, hdl-c increased 8, 42% reduction in death from heart attack, absolute chd mortality was reduced from.
